complications - continental - data - estimated - etiology
febrile - incidence - inflammation - irritation - maintained
outbreaks - patients - providers - treatment
History and Definition
Kawasaki syndrome (KS), also known as Kawasaki disease, is an acute _______ illness of unknown _______ that primarily affects children younger than 5 years of age. KS was first described in Japan by Tomisaku Kawasaki in 1967, and the first cases outside of Japan were reported in Hawaii in 1976.
KS is _______ by fever, rash, swelling of the hands and feet, _______ and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and _______ of the mouth, lips, and throat. Serious _______ of KS include coronary artery dilatations and aneurysms, and KS is a leading cause of acquired heart disease in the United States. The standard _______ with intravenous immunoglobulin and aspirin substantially decreases the development of these coronary artery _______ .
KS occurs worldwide, with the highest _______ in Japan, and it most often affects boys and younger children. KS may have a winter-spring seasonality, and community-wide _______ have been reported occasionally. In the _______ United States, population-based and hospitalization studies have estimated an incidence of KS ranging from 9 to 19 per 100,000 children younger than 5 years of age. _______ 4248 hospitalizations with KS, of which 3277 (77%) were for children under 5 years of age, were estimated among children younger than 18 years of age in the United States in the year 2000. In 2009, the _______ number of hospitalizations with KS was 5447 (standard error [SE] = 297); 4040 (SE = 227) for children < 5 years of age.
CDC uses hospital discharge _______, a passive KS surveillance system, and special studies to describe the incidence and epidemiology of KS in the United States. The KS surveillance system has been _______ by CDC since 1976 and is based on voluntary reporting of KS cases by health care _______ and local and state health authorities. A standardized case report form is used to collect information on _______.