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1 Understanding Autism

5/28/2016

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advance - coding - de novo - deletions - developing - devoid - establishing - formation - inherited - insight - linked - mutations - obtaining  - personalized - risk - symptoms  - transmitted - unscathed - variation - vibrant
1. New study finds genetic clues to autism
by Brett Smith 

A new study published in the journal Nature Genetics has found that mothers without_______of autism may pass on genetic  _______ factors for the developmental condition to their sons. 

The study included genetic information from nearly 2,400 children with autism and by examining families with one child with autism and one or more children _______ of the condition, the scientists gathered new data on how various kinds of _______ impact autism risk.

The researchers said their genetic information was acquired from exome sequencing, which looks at just the protein-_______ parts of the genome.

"The ability to examine these two types of genetic _______ in exome sequencing data is the first step toward _______ a more complete genetic picture at an individual level in the context of autism," noted the study team, from the University of Washington and Baylor College of Medicine, in a statement.

Focusing on other mutations

Past research has focused on _______ mutations, or mutations that show up in the child but not in either parent. Some cases of autism can be _______ to these mutations, but not all.


Instead of focusing on de novo mutations, the study team focused on other kinds of mutations, including those _______ from the mother or father. In particular, they quantified the autism risk of passed down gene mutations that cut off the _______ of proteins. They were especially interested in those proteins that are generally _______ in the volunteers unaffected by autism.

The scientists learned that the effect was most powerful when they detected mutations _______ from mothers to sons. This observation suggests a female may harbor such mutations without _______ autism, but when the mutations are passed along to her male offspring, the boys are at risk of _______ the condition.

The study also supplied one of the most _______ genetic pictures of autism to date. The scientists were able to compare both small mutations of single base-pairs in DNA and larger _______ and duplications of the genome.

"These findings are a major _______ in understanding the genes that play a role in autism," said study author Raphael Bernier, associate professor of psychology and behavioral sciences at the University of Washington. "Knowing more about these genes will set the stage for _______ medicine by allowing for targeted treatments specific to an individual. This gives parents more _______ and information about their child's condition."
Answers

​This homework is based from the book Understanding Autism
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7 Fear of Cancer and Feeling Terrible 

5/27/2016

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a - ago - and - any - at - from - in - of - off - on - to - under - when - with
Doctor: What brought you in today?
Patient: I've just been feeling terrible. I'm very busy. I'm taking tonics and things. It used to come _______ go, but now stays put. I can imagine everything. It all started nine months _______.
Doctor: When did you get _______ the stage when it was not getting any better?
Patient: A month ago. When I was _______ vacation, I felt fine. When I got back, I felt groggy again. It comes and it goes.
Doctor: How do you feel _______ it is bad?
Patient: I sleep badly. I imagine everything _______ the sun.
Doctor: Well, what specifically do you think of?
Patient: I think _______ cancer. The pain doesn't stay still. It moves _______ top to bottom.
Doctor: Do you have pain _______ you are worrying?
Patient: Yes.
Doctor: Do you have it _______ night?
Patient: Yes, I wake up _______ it and can't sleep again.
Doctor: What else have you noticed?
Patient: I've lost _______ few pounds.
Doctor: How's your appetite?
Patient: Quite good usually, but yesterday I couldn't eat a thing. When I feel really low, I can't eat anything. People _______ work have noticed I'm not well.
Doctor: You are 59 _______ a commercial artist. Have you any worries?
Patient: No. The boss _______ times is a bit grumpy, but...
Doctor: Are you usually cheerful?
Patient: Yes
Doctor: Have you felt low before?
Patient: Yes. I came here. I had palpitations.
Doctor: Has anything started this _______?
Patient: No.
Doctor: What about your urine? Do you get up _______ the night?
Patient: I get up once.
Doctor: And your bowels?
Patient: All right.
Doctor: Do you smoke?
Patient: 15 cigarettes _______ day.
Doctor: Drink?
Patient: No.
Doctor: Have you had any serious illness _______ the past?
Patient: Appendicitis _______ I was 15.
Doctor: Do you suffer _______ headaches?
Patient: No, not normally.
Doctor: Are you married?
Patient: Yes.
Doctor: Has your wife noticed _______ changes?
Patient: I'm depressed and tearful. Nervousness runs _______ the family. I've two brothers and three sisters all _______ nerves.
Answers
This homework based on the book Manual of English for the Overseas Doctor
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Overview

5/25/2016

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affects - care - contact - likely -  descent - diagnose -  genders - genetics  - infection - lymph – occur - passed  - prevented -  rare  - recover - researchers - risks
Use the vocabulary above and check here  for the answers when you finish

​Outlook 

Kawasaki disease can't be 
_______. However, most children who have the disease usually _______ within weeks of getting symptoms. Further problems are rare. 

The disease 
_______ some children's coronary arteries, which can cause serious problems. These children need long-term _______ and treatment. 

_______ continue to look for the cause of Kawasaki disease and better ways to _______ and treat it. They also hope to learn more about long-term health _______, if any, for people who have had the disease. 

Other Names for Kawasaki Disease 
Kawasaki syndrome 
Mucocutaneous
_______ node syndrome 

What Causes Kawasaki Disease? 
The cause of Kawasaki disease isn't known. The body's response to a virus or
_______ combined with genetic factors may cause the disease. However, no specific virus or infection has been found, and the role of_______isn't known. 

Kawasaki disease can't be 
_______ from one child to another. Your child won't get it from close_______ with a child who has the disease. Also, if your child has the disease, he or she can't pass it to another child. 

Who Is at Risk for Kawasaki Disease? 
Kawasaki disease affects children of all races and ages and both
_______. It occurs most often in children of Asian and Pacific Island_______. 

The disease is more 
_______ to affect boys than girls. Most cases _______ in children younger than 5 years old. Kawasaki disease is _______ in children older than 8.

Answers
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56

5/25/2016

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Shrewd Translation Precedes Obama’s Decision to Visit Hiroshima
オバマ大統領の広島訪問決断に先立つ巧みな翻訳 
Picture
as - by - from - in - of - on - out - to
​(1_______) Japan we have a saying: “jewel beetle colored statement.”
日本には「玉虫色の声明」という言葉があります。


This refers (2_______) the buprestidae family of beetles that appear (3_______) a variety of different colors depending (4_______) what angle you view them from, and means a vague statement that can be interpreted in many different ways.
玉虫は見る角度によりさまざまな色に見えることから、いろいろと解釈できるあいまいな声明を意味します。


Before the G7 Ise-Shima Summit held this May, a meeting of G7 foreign ministers was held (5_______) Hiroshima in April.
今年5月のG7伊勢志摩サミットに先立ち、4月に広島外相会合が開かれました。


Some officials pointed (6_______) that the Japanese translation of the “Hiroshima declaration” adopted there was incorrect.
そこで採択された「広島宣言」の日本語訳は誤訳ではとの指摘が関係者からありました。


The original English text is (7_______) follows:
英語の原文は次の通りです。


The people (8_______) Hiroshima and Nagasaki experienced immense devastation and human suffering (9_______) a consequence of the atomic bombings and…


The Japanese translation released (10_______) the Ministry of Foreign Affairs is as follows:
外務省が発表した、日本語訳は次の通りです。


広島 及び 長崎 の 人々 は、原子爆弾投下 による 極 めて 甚大な 壊滅 と 非人間的な 苦難という 結末 を 経験 し……


The translated part in question (11_______) the original text is “human suffering.”
問題にされたのは、原文の「human suffering」の訳です。


Translated literally this is “jinteki kutsuu” (human suffering) but it was expressed (12_______) “hi-ningentekina kunan” (inhuman suffering).
文字通りに訳せば「人的苦痛」ですが「非人間的な苦難」という表現になっています。 
after - between - during - for - from - in - of - out  
​The original English text plays down the damage done (13_______) consideration of the position taken by the USA and other nations that possess the nuclear deterrent who believe that the atomic bombing hastened the end (14_______) the war.
英語の原文は原爆が戦争の終結を早めたとするアメリカなど核保有国の立場に配慮し、被害を抑えた表現をしています。


Some people have pointed (15_______) that the Ministry of Foreign Affairs’ translation emphasized the tragedy (16_______) consideration of the sensibilities of the Japanese people who, as the only nation having suffered (17_______) an atomic bombing have a deep aversion to nuclear weapons
外務省の訳は唯一の被爆国で核アレルギーのある日本人の心情を考慮し、悲惨さを誇張したと指摘する人もいます。


Expressions whose nuance differs (18_______) English and Japanese have been seen before.
英語と日本語のニュアンスが異なる表現はこれまでも見られました。


(19_______) instance, “The United Nations.” Originally it was a term used to refer to the allied nations (20_______) World War Two. And the same name is used even now that it has become an international organization.
たとえば、「The United Nations」。本来第二次世界大戦の連合国を指す言葉でした。 そして 国際機関 と なった 現在 も、 同じ 名前 が 使われて います。


However, in Japanese, to distinguish it (21_______) the translated term “Rengoukoku” used during the war, the name “Kokusai Rengou” was used (22_______) the war.
しかし、日本語では戦時中に使われた「連合国」と区別して、戦後は「国際連合」が使われました。


There are also cases where the reverse is true. “Ianfu” is generally translated (23_______) Japan as “comfort women,” but some countries use the term “sex slaves” to emphasize the criminality (24_______) the practice.
逆のケースもあります。従軍慰安婦は日本では一般的に「comfort women」と訳されますが、犯罪性を強調するために「sex slave」を使用する国もあります。
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What Is Kawasaki Disease?

5/20/2016

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​capillaries – contact - coronary - descent - inflamed - occur - oxygen-rich
palms  - races  -  response -  role - soles - symptoms - treatment - vasculitis
NATIONAL HEART, LUNG AND BLOOD INSTITUTE INFORMATION

What Is Kawasaki Disease?
Kawasaki disease is a rare childhood disease. It's a form of a condition called_________. This condition involves inflammation of the blood vessels.


In Kawasaki disease, the walls of the blood vessels throughout the body become _________. The disease can affect any type of blood vessel in the body, including the arteries, veins, and _________.


Sometimes Kawasaki disease affects the coronary arteries, which carry _________ blood to the heart. As a result, some children who have Kawasaki disease may develop serious heart problems.


Overview
The cause of Kawasaki disease isn't known. The body's _________ to a virus or infection combined with genetic factors may cause the disease. However, no specific virus or infection has been found, and the _________ of genetics isn't known.


The disease can't be passed from one child to another. Your child won't get it from close _________ with a child who has the disease. Also, if your child has the disease, he or she can't pass it to another child.


Kawasaki disease affects children of all _________ and ages and both genders. It occurs most often in children of Asian and Pacific Island _________. The disease is more likely to affect boys than girls. Most cases _________ in children younger than 5 years old.


One of the main _________ of Kawasaki disease is a fever that lasts longer than 5 days. The fever remains high even after _________ with standard childhood fever medicines.


Children who have the disease also may have red eyes, red lips, and redness on the _________ of their hands and _________ of their feet. These are all signs of inflamed blood vessels.


Early treatment helps reduce the risk of Kawasaki disease affecting the _________ arteries and causing serious problems.
Answers
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​84

5/20/2016

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​Middle-aged Men Having a Go at Lessons Traditionally Popular Among Women
女性に人気の習い事に、中高年男性が挑戦 
Picture
by - during - for - in - like - of - since - to - with
​Ballet and yoga classes are perennially popular (1________) women. Recently, more men have become interested (2________) taking lessons, too. Dance Studio taftaf, Ibaraki City, Osaka, holds ballet lessons (3________) men. Bearing (4_______) mind that some men might be resistant to wearing tights, lessons are done (5________) casual clothing such as T-shirts and suteteko (calf-length undershorts).
習い事の中でもバレエやヨガは、女性に根強い人気があります。最近では、男性も興味を示して習う人が増えてきました。大阪府茨木市にあるダンススタジオ、タフタフには、男性向けのバレエレッスンがあります。タイツ姿には抵抗があるという男性の声から、Tシャツにステテコと気軽な服装です。


Active dancer Nanae Mimata has been the instructor (6________) 2013. In the first half of the lesson, students perform calisthenics (7________) a Thera-Band – a rubber band used for physical rehabilitation – applied (8________) the feet. In the later half, they learn basic ballet forms (9________) following the teacher’s movements. These include graceful movements (10________) balancing on one foot, stretching their arms (11________) the side, or drawing circles above their heads. Swing jazz is typically played (12________) the lesson.
2013年から、現役ダンサーの三股ナナエさんが指導しています。レッスン前半は、セラバンドと呼ばれるリハビリ用のゴムを足にかけた柔軟運動などを行います。後半は講師の動きに合わせてバレエの基本的な形を習います。片足を上げてバランスを取り、手を真横に伸ばしたり、頭の上で丸く円を描いたりといった優雅な動きです。レッスン中はスイングジャズが流れているのが特徴です。


Masutomi Koga, who began taking this class a year ago, says, “It is fun because, instead (13________) the usual piano pieces, we use jaunty music.” Hiroshi Sakurai, who has been taking lessons (14________) the course began, says, “I started in order to improve my back strain and didn’t take it very seriously. It’s so tough that I break out (15________) a cold sweat and this changed my attitude towards ballet. If I don’t go (16________) class these days, my physical condition deteriorates.”
レッスンを始めて1年の古閑斗福さんは、「通常使われるピアノ曲ではなく、軽快な音楽なので楽しいです」。開講時から続けている桜井啓さんは、「ぎっくり腰を改善したくて、冗談半分で始めました。油汗は出るし、きついしで、バレエの印象が変わりま した。今ではレッスンを休むと体の調子が悪くなります」と話します。 
along - at - for - in - of - on - over - through - with
​“Riverside Yoga” is periodically held (17________) the Okawa River in Chuo City, Osaka. Because of the sense (18________) freedom you get from practicing outdoors, not only women but also men participate. Takashi Juzu, representative and instructor (19________) Seikatsu Yoga Kenkyuujo, says that the company has been running lessons (20________) men since its foundation in 2011. “There are many men who wish to try yoga but are reluctant to do it (21________) women present. When they become accustomed to it, some men transfer to classes that have women (22________) them.”
大阪市中央区の大川沿いでは定期的に「リバーサイドヨガ」が行われています。屋外の開放感もあって、女性だけでなく男性も多く参加しています。生活ヨガ研究所の代表であり講師の珠数孝さんは、設立した2011年から男性専用の教室を開いています。「ヨガを始めたくても、女性がいると抵抗感を持つ人がたくさんいます。慣れて平気になると、女性と一緒のレッスンに移る人もいます」。


Hideyuki Sunada and Tetsuya Higashikawa wear T-shirts emblazoned (23________) the words: “Old Geezer Yoga.” Sunada, who has been doing yoga (24________) eight years, says, “There are discoveries to be made when taking a good look (25________) yourself. I found out that I had been putting too much pressure (26________) myself.” Higashikawa, who has been doing yoga (27________) four years, says, “By learning how to relax (28________) exhaling, changes have occurred in my body and heart.” (29________) with their classmates, the two men actively encourage men (30________) the age of 40 to take up yoga.
「おっさんヨガ」とプリントされたおそろいのTシャツを着た砂田秀之さんと東川哲也さんは話します。「自分と向き合うので発見があります。今までは肩に力が入っていたと気付きました」とヨガ歴8年の砂田さん。ヨガ歴4年の東川さんは、「息を吐いてリラックスすることを覚えて、体と心に変化が出てきました」と言います。二人は仲間たちと40代以上の男性へのヨガ普及活動を行っています。


“I think there are not many places where working men can attain mental equilibrium. I want these busy men to experience the benefits (31________) yoga,” says Juzu. (32________) the future, rather than going out drinking, perhaps more and more middle-aged men will be able to refresh both mind and body (33________) taking such classes.
「働く男性が心を整える場が、あまりないように思います。忙しい男性こそヨガで元気になってもらいたいですね」と、珠数さんは話します。酒場でリフレッシュではなく、習い事で心身を癒やす中高年男性が、これからも増えるかもしれません。
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CDC INFORMATION

5/13/2016

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​Abnormalities - approximately - characterized
complications - continental  -  data - estimated - etiology
febrile -  
incidence - inflammation - irritation - maintained
outbreaks - patients - providers - treatment
CDC INFORMATION
Kawasaki Syndrome
History and Definition

Kawasaki syndrome (KS), also known as Kawasaki disease, is an acute _______ illness of unknown _______ that primarily affects children younger than 5 years of age. KS was first described in Japan by Tomisaku Kawasaki in 1967, and the first cases outside of Japan were reported in Hawaii in 1976.

KS is _______ by fever, rash, swelling of the hands and feet, _______ and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and _______ of the mouth, lips, and throat. Serious _______ of KS include coronary artery dilatations and aneurysms, and KS is a leading cause of acquired heart disease in the United States. The standard _______ with intravenous immunoglobulin and aspirin substantially decreases the development of these coronary artery _______ .

KS occurs worldwide, with the highest _______ in Japan, and it most often affects boys and younger children. KS may have a winter-spring seasonality, and community-wide _______ have been reported occasionally. In the _______ United States, population-based and hospitalization studies have estimated an incidence of KS ranging from 9 to 19 per 100,000 children younger than 5 years of age. _______ 4248 hospitalizations with KS, of which 3277 (77%) were for children under 5 years of age, were estimated among children younger than 18 years of age in the United States in the year 2000. In 2009, the _______ number of hospitalizations with KS was 5447 (standard error [SE] = 297); 4040 (SE = 227) for children < 5 years of age.

CDC uses hospital discharge _______, a passive KS surveillance system, and special studies to describe the incidence and epidemiology of KS in the United States. The KS surveillance system has been _______ by CDC since 1976 and is based on voluntary reporting of KS cases by health care _______ and local and state health authorities. A standardized case report form is used to collect information on _______.
 Answers
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86

5/9/2016

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The Japanese and Adultery 
​
日本人と不倫  
Picture
about - by - despite - from - in - of - on - to - with
​Foreign Student (hereinafter FS): The adulterous affairs (1_______) celebrities or members of Parliament often appear (2_______) the news. How do the Japanese view adultery?
留学生(以下、留):芸能人や国会議員の不倫がよく報道されます 。日本人は不倫に対して どのような見方をしているのですか。


Teacher (hereinafter T): There was a news story (3_______) a female TV personality with a clean image – who had appeared (4_______) many TV commercials – having an affair (5_______) a vocalist in a band.
先生(以下、先):清潔感のあるイメージでたくさんのテレビコマーシャル に出ていた女性タレントがあるバンドボーカルと不倫をしていたというニュースがありました。


Although the weekly magazine that reported (6_______) this affair printed 20% more copies than usual, all of these sold out. So you might say that Japanese people are concerned (7_______) adultery among the famous.
それを報道した週刊誌は2割増刷しましたが、売り切れました。日本人は有名人の不倫に関心があるといえるでしょう。


In 2014 the news that France’s President Hollande was secretly meeting (8_______) an actress, despite already having a partner, caused quite a stir, even (9_______) Japan.
2014年にフランスのオランド大統領が、パートナーがいながら女優と密会したというニュースは日本でも話題になりました。
A survey (10_______) a French company revealed that 77% of French people felt that this was a private matter that just happened to concern the president. The Japanese were surprised (11_______) the tolerance of the French.
フランスの民間世論調査ではこれは個人的なことであり、たまたま大統領だっただけとする人が77%でした。日本人はフランス人の寛大さに驚きました。


In Japan, adultery is not punishable (12_______) law, but famous people are socially disgraced when their affairs are given widespread coverage (13________) the media.
日本では不倫は法的に処罰されませんが、有名人はメディアで大きく報道され、社会的に恥をさらすことになります。


In 1989 it was leaked (14_______) the media that an ex-geisha had been the lover of Japan’s Prime Minister UNO Sosuke.
1989年に元芸者が宇野宗佑総理大臣の愛人だったとメディアにリークしました。


It created a big fuss and he had to resign (15_______) his post as prime minister only two months after assuming office.
大騒ぎとなり、宇野総理は就任後2カ月余りでやめざるを得なくなりました。


FS: Wasn’t there also the adultery case (16_______) the member of the House of Representatives who had declared that he would set an example by taking paternity leave (17_______) the fact that in Japan it’s not common for men to take childcare leave?
留:男性が育児休暇をとりにくい日本で、率先して産休をとると表明した衆議院議員の不倫もありましたね。 
by - for - in - into - of - to
T: It was widely reported (18_______) the media that he committed adultery just before his wife – also a member (19_______) the House of Representatives – was about to deliver their baby and, as a result, he had to resign.
先:同じ議員である妻が出産する間際に不倫していたことがメディアで大きく報道され、結局辞職しました。


FS: Is adultery punishable conventionally (20_______) law anywhere in the world?
留:不倫に対して世界では一般的に法的な処罰があるのですか。


T: In some Islamic countries stoning is still practiced as a punishment and (21_______) some Asian countries adulterers are punished as criminals.
先:イスラム圏では石打ちの刑が今も行われている国があり、アジアでは犯罪者として処罰する国もあります。


(22_______) Japan about 1,000 years ago, husbands and wives did not live together, and it was common for a husband to make visits (23_______) his wife’s house. It is said that relations between men and women were more relaxed.
日本では、千年ほど前は夫と妻は同居せず、妻の家に夫が通うのが主流でした。男女関係はおおらかだったようです。


In the 18th century, it was made legal (24_______) men to punish their wives and the person their wives had committed adultery with.
18世紀には不倫した妻とその相手を処罰することが合法化されていました。


Later, adultery became a serious crime, with men being put (25_______) jail after being paraded through the city streets and women being sentenced (26_______) death.
その後、不倫は大犯罪となり、男は市内を引き回された後に牢屋に入れられ、女は死罪となりました。


F: How are things nowadays?
留:現代はどうなのですか。


T: When the TV drama “Kinyoubi no Tsumatachi e” (To Wives on Fridays) was broadcast (27_______) 1983, because of its popularity, the term “furin” (adultery) became widespread.
先:1983年にテレビドラマ「金曜日の妻たちへ」が放映されて話題になり、不倫という言葉が広がりました。


In 1997 “Shitsurakuen” (Paradise Lost), a novel written (28_______) Junichi Watanabe that explored the theme of adultery, became a bestseller and was selected for the grand prize (29_______) the New Expressions and Buzzwords Competition.
1997年には不倫をテーマにした渡辺淳一の小説「失楽園」がベストセラーとなり、流行語大賞にもなりました。


(30_______) 2014 the TV drama “Hirugao” (Day Face), starring UETO Aya, caused quite a stir.
2014年には上戸彩主演のテレビドラマ「昼顔」も、話題になりました。


FS: What comments do people who have committed adultery make (31_______) the public?
留:不倫をした人は大衆にどのようなコメントをしているのですか。


T: (32_______) the past an actor remarked that “adultery is part of our culture,” and a president (33_______) a film company commented that, “I did not make an actress my lover. I only made my lover an actress.”
先:かつて、ある俳優は「不倫は文化」と発言しました。また、ある映画会社の社長は「私は女優を愛人にしたのではない。愛人を女優にしただけだ」と述べました。


Now that the Internet is so well developed, famous people who’ve had affairs have to take the only partially serious condemnation (34_______) the general public and adopt a pose of deep regret.
インターネットが発達した現代、不倫した有名人は面白半分の大衆から痛烈な批難を受けて、ひたすら謝るポーズを取っています。 
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8

5/2/2016

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How to Make Sure You Arrive at the Right Station 
​
目的の駅へ確実到着するには
Picture
as - at - for - on - to - through
(1_______) the rail system in Japan is well developed, many different railroad lines and many different kinds of trains run (2_______) urban stations.
日本では鉄道が発達していて、都会の駅にはさまざまな路線、また、さまざまな種類の電車が走っています。

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They include ordinary trains that stop (3_______) all the stations on the line or express trains that only stop (4_______) the major stations. In addition (5_______) these there are super express and special express trains. What they are called depends (6_______) the rail company.
各駅に停まる普通列車、主要な駅だけに停まる急行列車、さらに早い快速や特急などです。呼び方は鉄道会社により異なります


(7_______) the platform you should check whether your train will stop (8_______) your destination station.
ホームではあなたが乗る電車が目的の駅で停まるかどうかを確認してください。


You ought to be aware that many stations use different platforms depending (9_______) the kinds of train – (10_______) instance ordinary trains or express trains.
普通や急行など、電車の種類によってホームが異なる駅がたくさんあるので注意しましょう。 

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